Perifosine (KRX-0401)
Revision as of 16:51, 14 November 2014 by Jwarner (talk | contribs) (Created page with "==Mechanism of action== AKT and PI3K inhibitor ==Preliminary data== ===Hodgkin lymphoma=== # Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S,...")
Mechanism of action
AKT and PI3K inhibitor
Preliminary data
Hodgkin lymphoma
- Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S, Russo D, Marchianò A, Sorasio R, Dodero A, Farina L, Giordano L, Di Nicola M, Anichini A, Corradini P, Gianni AM. Phase II Study of Perifosine and Sorafenib Dual-Targeted Therapy in Patients with Relapsed or Refractory Lymphoproliferative Diseases. Clin Cancer Res. 2014 Sep 19. [Epub ahead of print] link to original article PubMed
History of changes in FDA indication
- 9/3/2009: Received FDA orphan drug designation for treatment of multiple myeloma.
- 7/9/2010: Received FDA orphan drug designation for treatment of neuroblastoma.