Large granular lymphocytic leukemia
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LGL with treatment indications
Cyclophosphamide +/- Prednisone
Regimen
- Cyclophosphamide (Cytoxan) 50 to 100 mg PO once per day
Stop if no response by 4 months, if response continue for 6 to 12 months, or stop if progression
References
- Bareau B, Rey J, Hamidou M, Donadieu J, Morcet J, Reman O, Schleinitz N, Tournilhac O, Roussel M, Fest T, Lamy T. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica. 2010 Sep;95(9):1534-41. Epub 2010 Apr 7. link to original article PubMed
- Lamy T, Loughran TP Jr. How I treat LGL leukemia. Blood. 2011 Mar 10;117(10):2764-74. Epub 2010 Dec 29. link to original article PubMed
- Go RS, Li CY, Tefferi A, Phyliky RL. Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. Blood. 2001 Jul 15;98(2):483-5. link to original article PubMed
Methotrexate +/- Prednisone
Regimen
- Methotrexate (MTX) 7.5 to 10mg/m2 PO once per week
- Prednisone (Sterapred) 1mg/kg PO once per day for one month then taper over 1 month
Stop if no response by 4 months, if response continue until progression
References
- Bareau B, Rey J, Hamidou M, Donadieu J, Morcet J, Reman O, Schleinitz N, Tournilhac O, Roussel M, Fest T, Lamy T. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica. 2010 Sep;95(9):1534-41. Epub 2010 Apr 7. link to original article PubMed
- Lamy T, Loughran TP Jr. How I treat LGL leukemia. Blood. 2011 Mar 10;117(10):2764-74. Epub 2010 Dec 29. link to original article PubMed