Hairy cell leukemia

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Hairy cell leukemia

Cladribine (Leustatin)

Regimen #1 (Chadha, et al. 2005)

• Cladribine (Leustatin) 0.1 mg/kg/day IV continuous infusion on days 1-7 (total dose per cycle: 0.7 mg/kg)

7-day course

Regimen #2 (Zenhäusern, et al. 2009)

• Cladribine (Leustatin) 0.14 mg/kg/day IV continuous infusion on days 1-5 (total dose per cycle: 0.7 mg/kg)

5-day course

Regimen #3 (Zenhäusern, et al. 2009)

• Cladribine (Leustatin) 0.14 mg/kg/day IV once daily on days 1, 8, 15, 22, and 29

5-week course

References

1. Chadha P, Rademaker AW, Mendiratta P, Kim B, Evanchuk DM, Hakimian D, Peterson LC, Tallman MS. Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience. Blood. 2005 Jul 1;106(1):241-6. Epub 2005 Mar 10. link to original article contains protocol PubMed
2. Zenhäusern R, Schmitz SF, Solenthaler M, Heim D, Meyer-Monard S, Hess U, Leoncini L, Bargetzi M, Rufener B, Tobler A. Randomized trial of daily versus weekly administration of 2-chlorodeoxyadenosine in patients with hairy cell leukemia: a multicenter phase III trial (SAKK 32/98). Leuk Lymphoma. 2009 Sep;50(9):1501-11. doi: 10.1080/10428190903131755. link to original article contains protocol PubMed

Pentostatin (Nipent)

Regimen

• Pentostatin (Nipent) 5 mg/m2 IV over 2 minutes once daily on days 1 & 2

14-day cycles, continued to the point of maximal response or treatment failure

Supportive medications:

• Allopurinol (Aloprim) 300 mg PO once daily in "the initial courses of treatment" for prophylaxis

References

1. Cassileth PA, Cheuvart B, Spiers AS, Harrington DP, Cummings FJ, Neiman RS, Bennett JM, O'Connell MJ. Pentostatin induces durable remissions in hairy cell leukemia. J Clin Oncol. 1991 Feb;9(2):243-6. link to original article contains protocol PubMed