Methotrexate (MTX)
General information
Class/mechanism: Folate analog, antimetabolite, interferes with DNA synthesis. Methotrexate inhibits dihydrofolic acid reductase, which catalyzes reactions that produce tetrahydrofolates, which are used in purine nucleotide and thymidylate synthesis.[1][2]
Route: IV, PO, IM, IT, intraarterial
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Methotrexate (MTX) patient drug information (Chemocare)[3]
- Methotrexate (MTX) patient drug information (UpToDate)[4]
Also known as
Abitrexate, Alltrex, Amethopterin, Antifolan, APO-Methotrexate, Artrait, Biometrox, Biotrexate, Caditrex, Cytotrexate, Ebetrexat, Emthexat, Emthexate, Emthexate PF, Emthexate S, Ervemin, Farmitrexat, Fauldmetro, Folex PFS, Folitrax, Hextrate, Ifamet, Imutrex,Ledertrexate, Ledertrexate Sodium, Ledertrexato, Lumexon, Matrex, Maxtrex, Medsatrexate, Merex, Metex, Methobax, Methoblastin, Methorex, Methotrexaat, Methotrexaat Sandoz, Methotrexat Biosyn, Methotrexat Ebewe, Methotrexate Bigmar, Methotrexate Bristol, Methotrexate DBL, Methotrexate Disodium, Methotrexate DUP, Methotrexate Ebewe, Methotrexate Farmos, Methotrexate Knoll, Methotrexate Lederle, Methotrexate LPF, Methotrexate Mayne, Methotrexate Merck, Methotrexate Paranova, Methotrexate R, Methotrexate Remedica, Methotrexate Singad, Methotrexate Sodium, Methotrexate Sodium Lederle, Methotrexate Teva, Methotrexate Wyeth, Methotrexat Lederle, Methotrexat Medac, Methotrexato, Methotrexat Ridupharm, Methotrexat Teva, Methotrexatum, Meticil, Metolate, Metotressato, Metotrexate, Metotrexato Asofarma, Metotrexato Chiesi, Metotrexato Dosa, Metotrexato Filaxis, Metotrexato Lederle, Metotrexato Martian, Metotrexato Microsules, Metotrexol, Metrex, Metrexan, Metrexato, Metrotex, Mexate, Miantrex CS, MTX, MTX Hexal, Neometho, Neotrexate, Novatrex, Oncotrex, Oncotrex-PF, O Trexat, P&U Methotrexate, Pharmatrexate, Ratio-Methotrexate, Remtrex, Reumatrex, Rextop, Rheumatrex, Tecnomet, Texate, Texate T, Texorate, Tratoben, Trav Methotrexate, Tremetex, Trexall, Trexan, Trexeron, Trixilem, Trixilem RU, Unitrexate, Vero Methotrexate, Zexate