Dacarbazine (DTIC)

Also known as DIC, DTIC-Dome, Imidazole Carboxamide.

General information

Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Hodgkin lymphoma
• Melanoma

Patient drug information

• Dacarbazine (DTIC) patient drug information (Chemocare)
• Dacarbazine (DTIC) patient drug information (UpToDate)