Tropisetron (Navoban)

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Mechanism of action

From NCI: "An indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5-HT3 receptors, resulting in suppression of chemotherapy-and radiotherapy-induced nausea and vomiting."

History of FDA approval

Not FDA-approved; available in several countries

Also known as

ICS 205-930, Setrovel