Dinaciclib (SCH-727965)

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Mechanism of action

A cyclin dependent kinase inhibitor that selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9.

Preliminary data

Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)

  1. Flynn J, Jones J, Johnson AJ, Andritsos L, Maddocks K, Jaglowski S, Hessler J, Grever MR, Im E, Zhou H, Zhu Y, Zhang D, Small K, Bannerji R, Byrd JC. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia. 2015 Jul;29(7):1524-9. Epub 2015 Feb 24. link to original article link to PMC article PubMed

Multiple myeloma

  1. Kumar SK, LaPlant B, Chng WJ, Zonder J, Callander N, Fonseca R, Fruth B, Roy V, Erlichman C, Stewart AK. Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single agent activity in patients with relapsed multiple myeloma. Blood. 2015 Jan 15;125(3):443-8. Epub 2014 Nov 13. link to original article link to PMC article PubMed
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