Example orders for 5-FU & high-dose Leucovorin (Roswell Park regimen - HDLV) in colon cancer

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5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV)

Original reference may be found at 5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (adjuvant) & 5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (metastatic)

Example regimen #1

• Folinic acid (Leucovorin) 500 mg/m2 IV over 2 hours on days 1, 8, 15, 22, 29, 36, given first
• Fluorouracil (5-FU) 500 mg/m2 IV push on days 1, 8, 15, 22, 29, 36, 1 hour after start of leucovorin

8-week cycles x 3-4 cycles for adjuvant therapy; in metastatic settings, given until progression of disease or unacceptable toxicity

Supportive medications:

• Prochlorperazine (Compazine) 10 mg PO 30 minutes prior to chemotherapy
• Ondansetron (Zofran) 8 mg IV prn nausea
• Dexamethasone (Decadron) 10 mg IV prn nausea

Hydration:

• 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.

Monitoring:

• Hold if patient has significant diarrhea/mucositis, ANC <1000, or platelets <100 and notify physician.