Paclitaxel, nanoparticle albumin-bound (Abraxane)

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Also known as ab-pac, albumin-bound paclitaxel, or nab-paclitaxel.

General information

Class/mechanism: Taxane, promotes assembly of microtubules, stablizes microtubules, preventing depolymerization. Paclitaxel interferes with the normal dynamic reorganization of microtubules that is necessary for regular interphase/mitosis processes. It also leads to creation of abnormal bundles of microtubules. The nanoparticle albumin bound characteristic of Abraxane eliminates the need for it to be dissolved in Cremophor EL (polyoxyethylated castor oil) like Paclitaxel (Taxol) and the risk of hypersensitivity infusion reactions related to Cremophor.[1][2]
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

References

  1. ↑ 1.0 1.1 1.2 Paclitaxel, albumin-bound (Abraxane) package insert
  2. ↑ Paclitaxel, albumin-bound (Abraxane) package insert (locally hosted backup)
  3. ↑ Paclitaxel, nanoparticle albumin-bound (Abraxane) patient drug information (UpToDate)
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