Leucovorin (Folinic acid)

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General information

Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.[1][2]
Route: PO, IM, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

References

  1. ↑ 1.0 1.1 Folinic acid (Leucovorin) package insert
  2. ↑ Folinic acid (Leucovorin) package insert (locally hosted backup)
  3. ↑ Folinic acid (Leucovorin) patient drug information (Chemocare)
  4. ↑ Folinic acid (Leucovorin) patient drug information (UpToDate)
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