Prostate cancer tests

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PSA

• Increased PSA correlates with risk of prostate cancer and risk of aggressive prostate cancer, but does not mean that somebody has prostate cancer
• May be transiently elevated due to:
  • Enlarged prostate, benign prostatic hypertrophy (BPH)
  • Infection (prostatitis)
  • Ejaculation/sexual activity
  • Digital rectal exam (DRE), prostate exam
  • Biopsies or other instrumentation

Free PSA

• Free PSA helps to futher stratify likelihood of detecting prostate cancer

PCA3

• PCA3 RNA urine test
  • PCA3.org

Oncotype DX Prostate

• Oncotype DX Prostate Genomic Health's Genomic Prostate Score (GPS) & prognostic prostate cancer assay

Prolaris

• Prolaris, Myriad's biomarker prognostic prostate cancer assay

Decipher

• Decipher, GenomeDx's genomic prognostic prostate cancer assay
  • "the Decipher Test uses the expression of these biomarkers to calculate the probability of clinical metastasis within 5 years of radical prostatectomy surgery, and within 3 years of successive PSA rise (biochemical recurrence)."