Daunorubicin (Cerubidine)

General information

Class/mechanism: Anthracycline, binds and intercalates between DNA base pairs. Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, resulting in single and double strand DNA breaks. May also inhibit polymerase activity and trigger free radical damage to DNA.^[1]^[2]
Route: IV
Extravasation: vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

12/19/1979: Initial FDA approval

Also known as

Synonyms
Cerubidin	Cerubidine	D-Blastin	Daunoblastin	Daunoblastina
Daunocin	Daunomicina	Daunomycin	Daunorubicin	Daunorubicin Comp
Daunorubicine	Daunorubicin HCl	Daunorubicin Hydrochloride	Daunorubicin Lens	Daurocina
Maxidauno	Ondena	Rubidomycin	Rubilem	Rubomycin
Runabicon	Trav Daunorubicin

References

[insert-1] 1.0 ^1.1 Daunorubicin (Cerubidine) package insert

[2] Daunorubicin (Cerubidine) package insert (locally hosted backup)

[3] Daunorubicin (Cerubidine) patient drug information (Chemocare)

[4] Daunorubicin (Cerubidine) patient drug information (UpToDate)

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