Agatolimod (PF-3512676)

From HemOnc.org - A Hematology Oncology Wiki
Revision as of 00:44, 3 December 2022 by Jwarner (talk | contribs) (Created page with "==Mechanism of action== From the NCI Drug Dictionary: The tricosasodium salt of a synthetic 24-mer oligonucleotide containing 3 CpG motifs with potential antineoplastic and im...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Mechanism of action

From the NCI Drug Dictionary: The tricosasodium salt of a synthetic 24-mer oligonucleotide containing 3 CpG motifs with potential antineoplastic and immunostimulatory activity. Agatolimod selectively targets Toll-like receptor 9 (TLR9), thereby activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against tumor cells bearing tumor antigens.