Panitumumab (Vectibix)
Also known as ABX-EGF.
General information
Class/mechanism: EGFR antagonist; recombinant human IgG2 kappa monoclonal antibody that binds to EGFR (human epidermal growth factor receptor), competitively inhibiting binding of epidermal growth factor (EGF). EGFR is overexpressed in certain cancers, such as colon & rectal cancer, and plays a role in the signal transduction pathways that lead to transcription of genes that promote cell growth, survival, and motility. Blocking EGFR in a population overexpressing EGFR has been observed to inhibit cell growth and induce apoptosis.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Colon cancer
- Penile cancer (case report listed in the NCCN Guidelines, Penile Cancer version 1.2013)
Patient drug information
- Panitumumab (Vectibix) patient drug information (Chemocare)[4]
- Brief patient counseling information can be found on page 15 of the Panitumumab (Vectibix) package insert[1]
- Panitumumab (Vectibix) patient drug information (UpToDate)[5]