Pralsetinib (Gavreto)
Jump to navigation
Jump to search
Mechanism of action
From the [NCI Drug Dictionary]: An orally bioavailable selective inhibitor of mutant forms of and fusion products involving the proto-oncogene receptor tyrosine kinase RET, with potential antineoplastic activity. Upon administration, BLU-667 binds to and targets various RET mutants and RET-containing fusion product.
Diseases for which it is used
History of changes in FDA indication
- 9/4/2020: Granted accelerated approval for adult patients with metastatic RET fusion-positive non-small cell lung cancer (NSCLC)
Also known as
- Code name: BLU-667
- Brand name: Gavreto