Eosinophilia

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Definition

• Mild eosinophilia: Absolute eosinophil count 500 to 1500 cells/uL
• Moderate eosinophilia: Absolute eosinophil count 1500 to 5000 cells/uL
• Severe eosinophilia: Absolute eosinophil count >5000 cells/uL

Evaluation

May consist of:

• CBC with differential
• Comprehensive metabolic panel (CMP)
• Peripheral smear
• Vitamin B12
• Troponin I
• CK
• ANCA
• Strongyloides Antibody
• CHIC2, 4q12 Deletion (FIP1L1 and PDGFRA Fusion) FISH.
• T-Cell Receptor Gene Rearrangement PCR.
• Flow cytometry
• BCR-ABL FISH
• Immunoglobulins IgG, IgA, IgM
• Cortisol
• HIV, HTLV-I, HTLV-II serologies
• Serum tryptase
• Stool ova and parasites
• Chest x-ray
• Echocardiogram
• CT scans to evaluate for pulmonary pathology, lymphadenopathy
• Bone marrow biopsy
• Pulmonary function tests (PFTs)
• Clinical/infection history, international travel
• Medications