Example orders for Cetuximab (Erbitux) in colon cancer
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Cetuximab (Erbitux)
Original reference may be found at Cetuximab (Erbitux)
Example regimen #1
For cycle 1:
- Cetuximab (Erbitux) 400 mg/m2 IV over 120 minutes on day 1
- Use non-DEHP/paclitaxel tubing.
- Cetuximab (Erbitux) 250 mg/m2 IV over 60 minutes on days 8, 15, 22
- Use non-DEHP/paclitaxel tubing.
28-day cycle
Supportive medications:
- Acetaminophen (Tylenol) 650 mg PO 30 minutes prior to cetuximab
- Diphenhydramine (Benadryl) 50 mg IV 30 minutes prior to cetuximab
Hydration:
- 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.
Monitoring:
- Hold if ANC <1000 or platelets <100 and notify physician.
For cycle 2 and later:
- Cetuximab (Erbitux) 250 mg/m2 IV over 60 minutes on days 1, 8, 15, 22
- Use non-DEHP/paclitaxel tubing.
28-day cycles
Supportive medications:
- Acetaminophen (Tylenol) 650 mg PO 30 minutes prior to cetuximab
- Diphenhydramine (Benadryl) 50 mg IV 30 minutes prior to cetuximab
Hydration:
- 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.
Monitoring:
- Hold if ANC <1000 or platelets <100 and notify physician.
Comments:
- My institution uses 28-day cycles for Cetuximab (Erbitux) regimens.