Melphalan (Alkeran)

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Also known as L-PAM, L-Sarcolysin, or Phenylalanine.

General information

Class/mechanism: Nitrogen mustard, alkylator. Melphalan is a bischloroethylamine alkylating agent that crosslinks DNA by binding at the N7 position of guanine, with activity against resting and proliferating cells.[1][2]
Route: IV, PO
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

References

  1. ↑ 1.0 1.1 Melphalan (Alkeran) package insert
  2. ↑ Melphalan (Alkeran) package insert (locally hosted backup)
  3. ↑ Melphalan (Alkeran) patient drug information (Chemocare)
  4. ↑ Melphalan (Alkeran) patient drug information (UpToDate)
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