NET of unknown primary

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Guidelines

Given the rapid change in evidence in many areas of hematology/oncology, readers are encouraged to consider any guideline published 5+ years ago to be for historical purposes, only.

ESMO

• 2015: Cancers of unknown primary site: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up PubMed

NCCN

• NCCN Guidelines - Occult Primary (Cancer of Unknown Primary (CUP)

All lines of therapy

• Poorly differentiated or small cell tumors can be treated with small cell lung cancer regimens.
• Moderate to well-differentiated neuroendocrine tumors can be treated with regimens for neuroendocrine tumors.