Temozolomide (Temodar)
General information
Class/mechanism: Alkylator. Temozolmide is converted in vivo to the reactive compound 5-(3-methyltriazen-
1-yl)-imidazole-4-carboxamide (MTIC). MTIC causes alkylation of DNA at the O6 and N7 positions of guanine, leading to cell damage and cell death.[1][2][3]
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Temozolomide (Temodar) patient drug information from manufacturer[4]
- Temozolomide (Temodar) patient drug information (Chemocare)[5]
- Temozolomide (Temodar) patient drug information (UpToDate)[6]
References
- ↑ 1.0 1.1 Temozolomide (Temodar) package insert
- ↑ Temozolomide (Temodar) package insert (locally hosted backup)
- ↑ Temodar manufacturer's website
- ↑ Temozolomide (Temodar) patient drug information from manufacturer
- ↑ Temozolomide (Temodar) patient drug information (Chemocare)
- ↑ Temozolomide (Temodar) patient drug information (UpToDate)