Difference between revisions of "Ganitumab (AMG-479)"
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| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert. |
==Patient drug information== | ==Patient drug information== | ||
Revision as of 14:52, 23 January 2012
in clinical trials
General information
Class/mechanism: Human monoclonal antibody that targets IGF-1R (insulin-like growth factor 1 receptor). IGF-1R plays a role in cell survival and cell cycle progression via the PI3K/Akt pathway. Ganitumab's mechanism of action may involve: 1. inhibition of binding of IGF-1 and IGF-2 to IGF-1R; 2. blocking the action of IGF-1R homodimers and IGF-1R/INSR (insulin receptor) hybrid receptors; 3. downregulating expession of IGF-1R.[1][2]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert.
Patient drug information
No information available