Difference between revisions of "Etoposide (Vepesid)"
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m (moved Etoposide (Vepesid, VP-16) to Etoposide (Vepesid) over redirect) |
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| + | Also known as VP-16. | ||
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://packageinserts.bms.com/pi/pi_etopophos.pdf Etoposide (Vepesid) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/etoposide .pdf Etoposide (Vepesid) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Topoisomerase inhibitor. Causes DNA strand breaks by interacting with DNA-topoisomerase II or by forming free radicals. Causes the G2 portion of the cell cycle, with dose dependent effects: at high concentrations, cells entering mitosis undergo lysis; at low concentrations, cells are inhibited from entering prophase.<ref name="insert">[http://packageinserts.bms.com/pi/pi_etopophos.pdf Etoposide (Vepesid) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/etoposide.pdf Etoposide (Vepesid) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: [[irritant]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
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==Patient drug information== | ==Patient drug information== | ||
*[http://chemocare.com/bio/etoposide.asp Etoposide (Vepesid) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/etoposide.asp Etoposide (Vepesid) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/etoposide.asp Etoposide (Vepesid) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/etoposide.asp Etoposide (Vepesid) patient drug information (Chemocare)]</ref> | ||
| − | *[http://www.uptodate.com/contents/etoposide -patient-drug-information Etoposide (Vepesid) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/etoposide -patient-drug-information Etoposide (Vepesid) patient drug information (UpToDate)]</ref> | + | *[http://www.uptodate.com/contents/etoposide-patient-drug-information Etoposide (Vepesid) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/etoposide-patient-drug-information Etoposide (Vepesid) patient drug information (UpToDate)]</ref> |
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 03:46, 14 January 2012
Also known as VP-16.
General information
Class/mechanism: Topoisomerase inhibitor. Causes DNA strand breaks by interacting with DNA-topoisomerase II or by forming free radicals. Causes the G2 portion of the cell cycle, with dose dependent effects: at high concentrations, cells entering mitosis undergo lysis; at low concentrations, cells are inhibited from entering prophase.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Etoposide (Vepesid) patient drug information (Chemocare)[3]
- Etoposide (Vepesid) patient drug information (UpToDate)[4]