Difference between revisions of "Nivolumab and relatlimab (Opdualag)"
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
| − | * | + | *2022-03-18: Approved for adult and pediatric patients 12 years of age or older with unresectable or metastatic [[melanoma]]. ''(Based on RELATIVITY-047)'' |
==History of changes in EMA indication== | ==History of changes in EMA indication== | ||
| − | * | + | *2022-09-15: initial authorization for the first line treatment of advanced (unresectable or metastatic) [[melanoma]] in adults and adolescents 12 years of age and older with tumour cell PD L1 expression < 1%. |
==Also known as== | ==Also known as== | ||
*'''Code name:''' BMS-986016 | *'''Code name:''' BMS-986016 | ||
Latest revision as of 14:11, 7 May 2023
Mechanism of action
From the NCI Drug Dictionary (for relatlimab): A monoclonal antibody directed against the inhibitor receptor lymphocyte activation gene-3 (LAG-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, relatlimab binds to LAG-3 on tumor infiltrating lymphocytes (TILs). This may activate antigen-specific T lymphocytes and enhance cytotoxic T cell-mediated tumor cell lysis, which leads to a reduction in tumor growth.
Toxicity management
Diseases for which it is used
History of changes in FDA indication
- 2022-03-18: Approved for adult and pediatric patients 12 years of age or older with unresectable or metastatic melanoma. (Based on RELATIVITY-047)
History of changes in EMA indication
- 2022-09-15: initial authorization for the first line treatment of advanced (unresectable or metastatic) melanoma in adults and adolescents 12 years of age and older with tumour cell PD L1 expression < 1%.
Also known as
- Code name: BMS-986016
- Generic name: nivolumab and relatlimab-rmbw
- Brand name: Opdualag