Difference between revisions of "Amatuximab (MORAb-009)"
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Warner-admin (talk | contribs) m (Text replacement - "Mesothelioma" to "Malignant pleural mesothelioma") |
Warner-admin (talk | contribs) m (Text replacement - "0 PubMed]" to "0/ PubMed]") |
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==Preliminary data== | ==Preliminary data== | ||
===[[Malignant pleural mesothelioma]]=== | ===[[Malignant pleural mesothelioma]]=== | ||
− | # Hassan R, Kindler HL, Jahan T, Bazhenova L, Reck M, Thomas A, Pastan I, Parno J, O'Shannessy DJ, Fatato P, Maltzman JD, Wallin BA. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res. 2014 Dec 1;20(23):5927-36. Epub 2014 Sep 17. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252585/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/25231400 PubMed] | + | # Hassan R, Kindler HL, Jahan T, Bazhenova L, Reck M, Thomas A, Pastan I, Parno J, O'Shannessy DJ, Fatato P, Maltzman JD, Wallin BA. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res. 2014 Dec 1;20(23):5927-36. Epub 2014 Sep 17. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252585/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/25231400/ PubMed] |
==Also known as== | ==Also known as== |
Latest revision as of 13:22, 26 April 2023
Mechanism of action
From the NCI Drug Dictionary: A humanized IgG1 monoclonal antibody directed against human mesothelin with potential antineoplastic activity. Amatuximab binds to mesothelin, triggering an antibody dependent cellular cytotoxicity (ADCC)-mediated host immune response against mesothelin-expressing tumor cells, which may result in tumor cell lysis. Mesothelin, a 40kDa cell surface glycoprotein, is overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinomas.
Preliminary data
Malignant pleural mesothelioma
- Hassan R, Kindler HL, Jahan T, Bazhenova L, Reck M, Thomas A, Pastan I, Parno J, O'Shannessy DJ, Fatato P, Maltzman JD, Wallin BA. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res. 2014 Dec 1;20(23):5927-36. Epub 2014 Sep 17. link to PMC article PubMed
Also known as
- Code name: MORAb-009