Difference between revisions of "Dactinomycin (Cosmegen)"
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| − | *[ | + | *[https://chemocare.com/chemotherapy/drug-info/dactinomycin.aspx Dactinomycin (Cosmegen) patient drug information (Chemocare)]<ref>[https://chemocare.com/chemotherapy/drug-info/dactinomycin.aspx Dactinomycin (Cosmegen) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]</ref> | ||
Revision as of 21:54, 16 December 2021
General information
Class/mechanism: Antibiotic oncologic, intercalates between guanine and cytosine DNA base pairs, inhibiting DNA and RNA synthesis.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Endometrial cancer
- Ewing sarcoma
- Gestational trophoblastic neoplasia
- Osteosarcoma
- Rhabdomyosarcoma
- Wilms tumor
Patient drug information
- Dactinomycin (Cosmegen) patient drug information (Chemocare)[3]
- Dactinomycin (Cosmegen) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/10/1964: Initial FDA approval
- 3/13/2009: (earliest label available on Drugs@FDA) Approved as part of a combination chemotherapy and/or multi-modality treatment regimen for the treatment of Wilms tumor, childhood rhabdomyosarcoma, Ewing sarcoma and metastatic, nonseminomatous testicular cancer.
- 3/13/2009: (earliest label available on Drugs@FDA) Approved as a single agent, or as part of a combination chemotherapy regimen, for the treatment of gestational trophoblastic neoplasia.
- 3/13/2009: (earliest label available on Drugs@FDA) Approved as a component of regional perfusion for the palliative and/or adjunctive treatment of locally recurrent or locoregional solid malignancies.
Also known as
- Generic names: AC-DE, actinomycin D
- Brand names: Cosmegen, Dacmozen, Lyovac