Difference between revisions of "Daunorubicin (Cerubidine)"

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Also known as daunomycin, daunomycin cerubidine, daunorubicin hydrochloride, or rubidomycin hydrochloride.
 
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==General information==
 
==General information==
 
Class/mechanism: Anthracycline, binds and intercalates between DNA base pairs.  Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, resulting in single and double strand DNA breaks.  May also inhibit polymerase activity and trigger free radical damage to DNA.<ref name="insert">[http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Ben+Venue_Bedford+Labs/55390-108-01+DNOP_AQ+20mg/5539010801 Daunorubicin (Cerubidine) package insert]</ref><ref>[[Media:Daunorubicin.pdf | Daunorubicin (Cerubidine) package insert (locally hosted backup)]]</ref>
 
Class/mechanism: Anthracycline, binds and intercalates between DNA base pairs.  Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, resulting in single and double strand DNA breaks.  May also inhibit polymerase activity and trigger free radical damage to DNA.<ref name="insert">[http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Ben+Venue_Bedford+Labs/55390-108-01+DNOP_AQ+20mg/5539010801 Daunorubicin (Cerubidine) package insert]</ref><ref>[[Media:Daunorubicin.pdf | Daunorubicin (Cerubidine) package insert (locally hosted backup)]]</ref>
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*[http://chemocare.com/chemotherapy/drug-info/daunorubicin.aspx Daunorubicin (Cerubidine) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/daunorubicin.aspx Daunorubicin (Cerubidine) patient drug information (Chemocare)]</ref>
 
*[http://chemocare.com/chemotherapy/drug-info/daunorubicin.aspx Daunorubicin (Cerubidine) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/daunorubicin.aspx Daunorubicin (Cerubidine) patient drug information (Chemocare)]</ref>
 
*[http://www.uptodate.com/contents/daunorubicin-patient-drug-information Daunorubicin (Cerubidine) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/daunorubicin-patient-drug-information Daunorubicin (Cerubidine) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/daunorubicin-patient-drug-information Daunorubicin (Cerubidine) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/daunorubicin-patient-drug-information Daunorubicin (Cerubidine) patient drug information (UpToDate)]</ref>
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==History of changes in FDA indication==
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* 12/19/1979: Initial FDA approval
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==Also known as==
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{| border="1" style="text-align:center;"
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!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
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|-
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|Cerubidin
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|Cerubidine
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|D-Blastin
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|Daunoblastin
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|Daunoblastina
 +
|-
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|Daunocin
 +
|Daunomicina
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|Daunomycin
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|Daunorubicin
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|Daunorubicin Comp
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|-
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|Daunorubicine
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|Daunorubicin HCl
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|Daunorubicin Hydrochloride
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|Daunorubicin Lens
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|Daurocina
 +
|-
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|Maxidauno
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|Ondena
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|Rubidomycin
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|Rubilem
 +
|Rubomycin
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|-
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|Runabicon
 +
|Trav Daunorubicin
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|}
  
 
==References==
 
==References==
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[[Category:Anthracyclines]]
 
[[Category:Anthracyclines]]
 
[[Category:Topoisomerase inhibitors]]
 
[[Category:Topoisomerase inhibitors]]
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[[Category:Acute lymphocytic leukemia medications]]
 
[[Category:Acute lymphocytic leukemia medications]]
 
[[Category:Acute myeloid leukemia medications]]
 
[[Category:Acute myeloid leukemia medications]]
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[[Category:Acute promyelocytic leukemia medications]]
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[[Category:Drugs FDA approved in 1979]]

Revision as of 14:31, 1 November 2014

General information

Class/mechanism: Anthracycline, binds and intercalates between DNA base pairs. Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, resulting in single and double strand DNA breaks. May also inhibit polymerase activity and trigger free radical damage to DNA.[1][2]
Route: IV
Extravasation: vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 12/19/1979: Initial FDA approval

Also known as

Synonyms
Cerubidin Cerubidine D-Blastin Daunoblastin Daunoblastina
Daunocin Daunomicina Daunomycin Daunorubicin Daunorubicin Comp
Daunorubicine Daunorubicin HCl Daunorubicin Hydrochloride Daunorubicin Lens Daurocina
Maxidauno Ondena Rubidomycin Rubilem Rubomycin
Runabicon Trav Daunorubicin

References

  1. ↑ 1.0 1.1 Daunorubicin (Cerubidine) package insert
  2. ↑ Daunorubicin (Cerubidine) package insert (locally hosted backup)
  3. ↑ Daunorubicin (Cerubidine) patient drug information (Chemocare)
  4. ↑ Daunorubicin (Cerubidine) patient drug information (UpToDate)
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