Difference between revisions of "Cyclophosphamide (Cytoxan)"

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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/cytoxan-cyclophosphamide-342214 Medscape],[http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/cytoxan-cyclophosphamide-342214 Medscape],[http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
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==Diseases for which it is used==
 
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*[[Acute lymphocytic leukemia]]
 
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*[[Aggressive Non-Hodgkin lymphoma]]
 
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*[[Bladder cancer]]
 
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*[[Bone cancer]]
 
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*[[Breast cancer]]
 
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*[[Central nervous system (CNS) cancer]]
 
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*[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]]
 
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*[[Follicular lymphoma]]
 
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*[[Hodgkin lymphoma]]
 
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*[[Hodgkin lymphoma, nodular lymphocyte-predominant]]
 
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*[[HIV-associated lymphoma]]
 
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*[[Light-chain (AL) amyloidosis]]
 
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*[[Mantle cell lymphoma]]
 
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*[[Multiple myeloma]]
 
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*[[Neuroendocrine tumors]]
 
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*[[Prostate cancer]]
 
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*[[Small cell lung cancer]]
 
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*[[Thymoma]]
 
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*[[Transplant conditioning regimens]]
 
  
 
==Patient drug information==
 
==Patient drug information==
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==Also known as==
 
==Also known as==
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Alkyloxan, Biodoxan, Carloxan, Ciclofosfamida, Ciclofosfamida Filaxis, Ciclofosfamida Martian, Ciclokebir, Cyclam, Cycloblastin, Cycloblastine, Cyclo Cell, Cycloferon, Cyclomide, Cyclophar, Cyclophospham, Cyclophosphamid, cyclophosphamide monohydrate, Cyclophosphamid Farmos, Cyclophosphan, Cyclophosphan Lens, Cyclostin, Cycloxan, Cycram, Cydoxan, Cyklofosfamid, Cytophosphan, Cytoxan, Cytoxan Lyophilized, Endoxan, Endoxan-N, Endoxana, Endoxan Asta, Formitex, Genoxal, Genuxal, Hidrofosmin, Ledoxan, Ledoxina, Lyophilized Cytoxan, Neosar, Oncomide, Oncophos, Procytox, Revimmune, Sendoxan, Syklofosfamid, Trav Cyclophosphamide, Tymtran, Zycram
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{| border="1" style="text-align:center;"
 +
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
 +
|-
 +
|Alkyloxan
 +
|Biodoxan
 +
|Carloxan
 +
|Ciclofosfamida
 +
|Ciclofosfamida Filaxis
 +
|Ciclofosfamida Martian
 +
|Ciclokebir
 +
|Cyclam
 +
|-
 +
|Cycloblastin
 +
|Cycloblastine
 +
|Cyclo Cell
 +
|Cycloferon
 +
|Cyclomide
 +
|Cyclophar
 +
|Cyclophospham
 +
|Cyclophosphamid
 +
|-
 +
|cyclophosphamide monohydrate
 +
|Cyclophosphamid Farmos
 +
|Cyclophosphan
 +
|Cyclophosphan Lens
 +
|Cyclostin
 +
|Cycloxan
 +
|Cycram
 +
|Cydoxan
 +
|-
 +
|Cyklofosfamid
 +
|Cytophosphan
 +
|Cytoxan
 +
|Cytoxan Lyophilized
 +
|Endoxan
 +
|Endoxan-N
 +
|Endoxana
 +
|Endoxan Asta
 +
|-
 +
|Formitex
 +
|Genoxal
 +
|Genuxal
 +
|Hidrofosmin
 +
|Ledoxan
 +
|Ledoxina
 +
|Lyophilized Cytoxan
 +
|Neosar
 +
|-
 +
|Oncomide
 +
|Oncophos
 +
|Procytox
 +
|Revimmune
 +
|Sendoxan
 +
|Syklofosfamid
 +
|Trav Cyclophosphamide
 +
|Tymtran
 +
|-
 +
|Zycram
 +
|}
  
 
==References==
 
==References==
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[[Category:Alkylating agents]]
 
[[Category:Alkylating agents]]
 
[[Category:Nitrogen mustards]]
 
[[Category:Nitrogen mustards]]
 +
 
[[Category:Acute lymphocytic leukemia medications]]
 
[[Category:Acute lymphocytic leukemia medications]]
 +
[[Category:Aggressive Non-Hodgkin lymphoma medications]]
 
[[Category:Bladder cancer medications]]
 
[[Category:Bladder cancer medications]]
 
[[Category:Bone cancer medications]]  
 
[[Category:Bone cancer medications]]  
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[[Category:Multiple myeloma medications]]
 
[[Category:Multiple myeloma medications]]
 
[[Category:Neuroendocrine tumor medications]]
 
[[Category:Neuroendocrine tumor medications]]
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[[Category:Non-Hodgkin lymphoma medications]]
 
 
[[Category:Prostate cancer medications]]
 
[[Category:Prostate cancer medications]]
 
[[Category:Small cell lung cancer medications]]
 
[[Category:Small cell lung cancer medications]]
 
[[Category:Thymoma medications]]
 
[[Category:Thymoma medications]]
 
[[Category:Transplant medications]]
 
[[Category:Transplant medications]]

Revision as of 20:14, 11 June 2014

General information

Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.[1][2]
Route: IV, PO
Extravasation: irritant, n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Also known as

Synonyms
Alkyloxan Biodoxan Carloxan Ciclofosfamida Ciclofosfamida Filaxis Ciclofosfamida Martian Ciclokebir Cyclam
Cycloblastin Cycloblastine Cyclo Cell Cycloferon Cyclomide Cyclophar Cyclophospham Cyclophosphamid
cyclophosphamide monohydrate Cyclophosphamid Farmos Cyclophosphan Cyclophosphan Lens Cyclostin Cycloxan Cycram Cydoxan
Cyklofosfamid Cytophosphan Cytoxan Cytoxan Lyophilized Endoxan Endoxan-N Endoxana Endoxan Asta
Formitex Genoxal Genuxal Hidrofosmin Ledoxan Ledoxina Lyophilized Cytoxan Neosar
Oncomide Oncophos Procytox Revimmune Sendoxan Syklofosfamid Trav Cyclophosphamide Tymtran
Zycram

References

  1. ↑ 1.0 1.1 Cyclophosphamide (Cytoxan) package insert
  2. ↑ Cyclophosphamide (Cytoxan) package insert (locally hosted backup)
  3. ↑ Cyclophosphamide (Cytoxan) patient drug information (Chemocare)
  4. ↑ Cyclophosphamide (Cytoxan) patient drug information (UpToDate)
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