Belotecan (Camptobell)

General information

Class/mechanism from the NCI Drug Dictionary: The hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis.
Route: IV
Extravasation: irritant

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Diseases for which it is used

• Ovarian cancer
• Small cell lung cancer

Also known as

• Code name: CKD-602
• Generic name: belotecan hydrochloride
• Brand name: Camptobell