Difference between revisions of "Ruxolitinib (Jakafi)"
(Created page with "Also formerly known as INCB018424. ==General information== Class/mechanism: ATP mimetic JAK1 and JAK2 inhibitor <ref name="insert">[http://www.incyte.com/products/uspi_jakafi.pd...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: | + | Class/mechanism: kinase inhibitor of Janus Associated Kinases (JAKs) JAK1 and JAK2. Modulates gene expression by interfering with the JAK signaling pathway, which involves recruitment, activation, and localization of STATs (signal transducers and activators of transcription) to cytokine receptors and the nucleus.<ref name="insert">[http://www.incyte.com/products/uspi_jakafi.pdf Ruxolitinib (Jakafi) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/ruxolitinib.pdf Ruxolitinib (Jakafi) package insert (locally hosted backup)]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
Revision as of 18:25, 5 December 2011
Also formerly known as INCB018424.
General information
Class/mechanism: kinase inhibitor of Janus Associated Kinases (JAKs) JAK1 and JAK2. Modulates gene expression by interfering with the JAK signaling pathway, which involves recruitment, activation, and localization of STATs (signal transducers and activators of transcription) to cytokine receptors and the nucleus.[1][2]
Route: PO
Extravasation: n/a
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Patient drug information
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Regimens
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<acronym (if any)> <generic drug1, generic drug2, generic drug3, etc.> (disease)