Difference between revisions of "Floxuridine (FUDR)"
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*[http://chemocare.com/bio/floxuridine.asp Floxuridine (FUDR) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/floxuridine.asp Floxuridine (FUDR) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/floxuridine.asp Floxuridine (FUDR) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/floxuridine.asp Floxuridine (FUDR) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/floxuridine-patient-drug-information Floxuridine (FUDR) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/floxuridine-patient-drug-information Floxuridine (FUDR) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/floxuridine-patient-drug-information Floxuridine (FUDR) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/floxuridine-patient-drug-information Floxuridine (FUDR) patient drug information (UpToDate)]</ref> | ||
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| + | ==Disease for which it is used== | ||
| + | *[[Colon cancer]] | ||
==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
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[[Category:Fluoropyrimidines]] | [[Category:Fluoropyrimidines]] | ||
| + | [[Category:Colon cancer medications]] | ||
[[Category:FDA approved in 1970]] | [[Category:FDA approved in 1970]] | ||
Revision as of 16:16, 26 August 2018
General information
Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. When given by rapid intraarterial injection, it is rapidly catabolized in vivo to fluorouracil (5-FU), which is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP). When FUDR is given by continuous intraarterial infusion, direct anabolism to FUDR-monophosphate is enhanced, which increases the inhibition of DNA.[1][2]
Route: IA (intraarterial)
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Floxuridine (FUDR) patient drug information (Chemocare)[3]
- Floxuridine (FUDR) patient drug information (UpToDate)[4]
Disease for which it is used
History of changes in FDA indication
- 12/18/1970: Initial FDA approval
Also known as
- Code name: WR-138720
- Generic names: floxuridin, fluorodeoxyuridine, fluorouridine deoxyribose
- Brand name: FUDF