Difference between revisions of "Melphalan (Alkeran)"
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==General information== | ==General information== | ||
Class/mechanism: Nitrogen mustard, alkylator. Melphalan is a bischloroethylamine alkylating agent that crosslinks DNA by binding at the N7 position of guanine, with activity against resting and proliferating cells.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/014691s029lbl.pdf Melphalan (Alkeran) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/melphalan.pdf Melphalan (Alkeran) package insert (locally hosted backup)]</ref> | Class/mechanism: Nitrogen mustard, alkylator. Melphalan is a bischloroethylamine alkylating agent that crosslinks DNA by binding at the N7 position of guanine, with activity against resting and proliferating cells.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/014691s029lbl.pdf Melphalan (Alkeran) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/melphalan.pdf Melphalan (Alkeran) package insert (locally hosted backup)]</ref> | ||
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*[http://chemocare.com/bio/melphalan.asp Melphalan (Alkeran) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/melphalan.asp Melphalan (Alkeran) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/melphalan.asp Melphalan (Alkeran) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/melphalan.asp Melphalan (Alkeran) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/melphalan-patient-drug-information Melphalan (Alkeran) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/melphalan-patient-drug-information Melphalan (Alkeran) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/melphalan-patient-drug-information Melphalan (Alkeran) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/melphalan-patient-drug-information Melphalan (Alkeran) patient drug information (UpToDate)]</ref> | ||
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| + | ==Also known as== | ||
| + | Alkerana, L-PAM, L-Phenylalanine Mustard, L-Sacrolysin, L-Sarcolysin, Levofolan, Melfalan, Phenylalanine. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 03:59, 16 June 2013
General information
Class/mechanism: Nitrogen mustard, alkylator. Melphalan is a bischloroethylamine alkylating agent that crosslinks DNA by binding at the N7 position of guanine, with activity against resting and proliferating cells.[1][2]
Route: IV, PO
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Melphalan (Alkeran) patient drug information (Chemocare)[3]
- Melphalan (Alkeran) patient drug information (UpToDate)[4]
Also known as
Alkerana, L-PAM, L-Phenylalanine Mustard, L-Sacrolysin, L-Sarcolysin, Levofolan, Melfalan, Phenylalanine.