Difference between revisions of "Clofarabine (Clolar)"

From HemOnc.org - A Hematology Oncology Wiki
Jump to navigation Jump to search
Line 15: Line 15:
 
*Brief patient counseling information can be found at the bottom of [http://www.clolar.com/~/media/Files/Clolar/prescribing-information.pdf#page=2 page 2 of the package insert]<ref name="insert"></ref>
 
*Brief patient counseling information can be found at the bottom of [http://www.clolar.com/~/media/Files/Clolar/prescribing-information.pdf#page=2 page 2 of the package insert]<ref name="insert"></ref>
 
*[http://www.uptodate.com/contents/clofarabine-patient-drug-information Clofarabine (Clolar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/clofarabine-patient-drug-information Clofarabine (Clolar) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/clofarabine-patient-drug-information Clofarabine (Clolar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/clofarabine-patient-drug-information Clofarabine (Clolar) patient drug information (UpToDate)]</ref>
 +
 +
==History of changes in FDA indication==
 +
* 12/28/2004: Initial FDA approval
  
 
==References==
 
==References==

Revision as of 15:30, 6 June 2013

Also known as Evoltra.

General information

Class/mechanism: Purine analog, inhibits DNA synthesis and repair by inhibiting ribonucleotide reductase and competitively inhibiting DNA polymerases. It also causes apoptosis by disrupting the integrity of the mitochondrial membrane, triggering the release of cytochrome C and apoptosis-inducing factor, which are pro-apoptotic mitochondrial proteins.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 12/28/2004: Initial FDA approval

References