Difference between revisions of "Denileukin diftitox (Ontak)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Recombinant diphtheria toxin fusion protein which binds with high affinity to IL-2 receptors. The fusion protein is internalized by receptor-mediated endocytosis and is cleaved, releasing the diphtheria toxin, which inhibits protein synthesis and causes cell death.<ref name="insert">[http:// | + | Class/mechanism: Recombinant diphtheria toxin fusion protein which binds with high affinity to IL-2 receptors. The fusion protein is internalized by receptor-mediated endocytosis and is cleaved, releasing the diphtheria toxin, which inhibits protein synthesis and causes cell death.<ref name="insert">[http://us.eisai.com/pdf_files/Ontak_PI.pdf Denileukin diftitox (Ontak) package insert]</ref><ref>[[Media:Denileukindiftitox.pdf | Denileukin diftitox (Ontak) package insert (locally hosted backup)]]</ref><ref>[http://us.eisai.com/section.asp?ID=257 Ontak manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| − | *Cutaneous T-cell lymphoma (CTCL) | + | *[[T-cell lymphoma|Cutaneous T-cell lymphoma (CTCL)]] |
==Patient drug information== | ==Patient drug information== | ||
*[http://chemocare.com/chemotherapy/drug-info/denileukin-diftitox.aspx Denileukin diftitox (Ontak) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/denileukin-diftitox.aspx Denileukin diftitox (Ontak) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/chemotherapy/drug-info/denileukin-diftitox.aspx Denileukin diftitox (Ontak) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/denileukin-diftitox.aspx Denileukin diftitox (Ontak) patient drug information (Chemocare)]</ref> | ||
| − | *Brief patient counseling information can be found on [http:// | + | *Brief patient counseling information can be found on [http://us.eisai.com/pdf_files/Ontak_PI.pdf#page=5 page 5 of the Denileukin diftitox (Ontak) package insert]<ref name="insert"></ref> |
*[http://www.uptodate.com/contents/denileukin-diftitox-patient-drug-information Denileukin diftitox (Ontak) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/denileukin-diftitox-patient-drug-information Denileukin diftitox (Ontak) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/denileukin-diftitox-patient-drug-information Denileukin diftitox (Ontak) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/denileukin-diftitox-patient-drug-information Denileukin diftitox (Ontak) patient drug information (UpToDate)]</ref> | ||
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[[Category:Chemotherapy]] | [[Category:Chemotherapy]] | ||
[[Category:Immunotherapy]] | [[Category:Immunotherapy]] | ||
| − | [[Category: | + | [[Category:T-cell lymphoma medications]] |
Revision as of 15:45, 26 May 2013
General information
Class/mechanism: Recombinant diphtheria toxin fusion protein which binds with high affinity to IL-2 receptors. The fusion protein is internalized by receptor-mediated endocytosis and is cleaved, releasing the diphtheria toxin, which inhibits protein synthesis and causes cell death.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Denileukin diftitox (Ontak) patient drug information (Chemocare)[4]
- Brief patient counseling information can be found on page 5 of the Denileukin diftitox (Ontak) package insert[1]
- Denileukin diftitox (Ontak) patient drug information (UpToDate)[5]