Difference between revisions of "Waldenström macroglobulinemia"
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=Relapsed/Refractory= | =Relapsed/Refractory= | ||
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| + | ==Everolimus== | ||
| + | ===Regimen=== | ||
| + | *[[Everolimus (Afinitor)]] 10 mg PO once per day | ||
| + | |||
| + | '''28-day cycles, given until progression or unacceptable toxicity''' | ||
| + | |||
| + | ===References=== | ||
| + | # Ghobrial IM, Gertz M, Laplant B, Camoriano J, Hayman S, Lacy M, Chuma S, Harris B, Leduc R, Rourke M, Ansell SM, Deangelo D, Dispenzieri A, Bergsagel L, Reeder C, Anderson KC, Richardson PG, Treon SP, Witzig TE. Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. J Clin Oncol. 2010 Mar 10;28(8):1408-14. doi:10.1200/JCO.2009.24.0994. Epub 2010 Feb 8. [http://jco.ascopubs.org/content/28/8/1408.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20142598 PubMed] | ||
| + | |||
==Panobinostat== | ==Panobinostat== | ||
===Regimen=== | ===Regimen=== | ||
| − | *[[Panobinostat (LBH589)]] 30 mg PO 3 days | + | *[[Panobinostat (LBH589)]] 30 mg PO 3 days per week (Mondays, Wednesdays, and Fridays) |
'''28-day cycles, given until progression of disease''' | '''28-day cycles, given until progression of disease''' | ||
Revision as of 15:23, 24 May 2013
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Relapsed/Refractory
Everolimus
Regimen
- Everolimus (Afinitor) 10 mg PO once per day
28-day cycles, given until progression or unacceptable toxicity
References
- Ghobrial IM, Gertz M, Laplant B, Camoriano J, Hayman S, Lacy M, Chuma S, Harris B, Leduc R, Rourke M, Ansell SM, Deangelo D, Dispenzieri A, Bergsagel L, Reeder C, Anderson KC, Richardson PG, Treon SP, Witzig TE. Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. J Clin Oncol. 2010 Mar 10;28(8):1408-14. doi:10.1200/JCO.2009.24.0994. Epub 2010 Feb 8. link to original article contains verified protocol PubMed
Panobinostat
Regimen
- Panobinostat (LBH589) 30 mg PO 3 days per week (Mondays, Wednesdays, and Fridays)
28-day cycles, given until progression of disease
References
- Ghobrial IM, Campigotto F, Murphy TJ, Boswell EN, Banwait R, Azab F, Chuma S, Kunsman J, Donovan A, Masood F, Warren D, Rodig S, Anderson KC, Richardson PG, Weller E, Matous J. Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenstrom macroglobulinemia. Blood. 2013 Feb 21;121(8):1296-303. doi:10.1182/blood-2012-06-439307. Epub 2013 Jan 3. link to original article contains verified protocol PubMed