Difference between revisions of "Procarbazine (Matulane)"
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==General information== | ==General information== | ||
Class/mechanism: Hydrazine derivative, alkylator; exact mechanism not understood. May inhibit transmethylation of methionine methyl groups to tRNA, interfering with protein, RNA, and DNA synthesis. May also directly damage DNA.<ref name="insert">[http://www.matulane.com/pdf/prescribe-info.pdf Procarbazine (Matulane) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/procarbazine.pdf Procarbazine (Matulane) package insert (locally hosted backup)]</ref> | Class/mechanism: Hydrazine derivative, alkylator; exact mechanism not understood. May inhibit transmethylation of methionine methyl groups to tRNA, interfering with protein, RNA, and DNA synthesis. May also directly damage DNA.<ref name="insert">[http://www.matulane.com/pdf/prescribe-info.pdf Procarbazine (Matulane) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/procarbazine.pdf Procarbazine (Matulane) package insert (locally hosted backup)]</ref> | ||
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*[http://chemocare.com/bio/procarbazine.asp Procarbazine (Matulane) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/procarbazine.asp Procarbazine (Matulane) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/procarbazine.asp Procarbazine (Matulane) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/procarbazine.asp Procarbazine (Matulane) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/procarbazine-patient-drug-information Procarbazine (Matulane) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/procarbazine-patient-drug-information Procarbazine (Matulane) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/procarbazine-patient-drug-information Procarbazine (Matulane) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/procarbazine-patient-drug-information Procarbazine (Matulane) patient drug information (UpToDate)]</ref> | ||
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| + | ==Also known as== | ||
| + | Indicarb, Matulane, Natulan, Natulanar, P-Carbazine, P-Carzine, procarbazine HCl Chugaigai, procarbazine hydrochloride | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 16:08, 1 April 2013
General information
Class/mechanism: Hydrazine derivative, alkylator; exact mechanism not understood. May inhibit transmethylation of methionine methyl groups to tRNA, interfering with protein, RNA, and DNA synthesis. May also directly damage DNA.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Procarbazine (Matulane) patient drug information (Chemocare)[3]
- Procarbazine (Matulane) patient drug information (UpToDate)[4]
Also known as
Indicarb, Matulane, Natulan, Natulanar, P-Carbazine, P-Carzine, procarbazine HCl Chugaigai, procarbazine hydrochloride