Difference between revisions of "Vismodegib (Erivedge)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Basal cell carcinoma (BCC)]] | *[[Basal cell carcinoma (BCC)]] | ||
| + | *[[SMO or PTCH-1 (Hedgehog)|Hedgehog pathway-mutated tumors (tissue-agnostic)]] | ||
==Patient drug information== | ==Patient drug information== | ||
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[[Category:Basal cell carcinoma (BCC) medications]] | [[Category:Basal cell carcinoma (BCC) medications]] | ||
| + | [[Category:SMO or PTCH-1 (Hedgehog) medications]] | ||
[[Category:Drugs FDA approved in 2012]] | [[Category:Drugs FDA approved in 2012]] | ||
Revision as of 20:28, 26 April 2018
General information
Class/mechanism: Hedgehog pathway inhibitor. Vismodegib binds to and inhibits the transmembrane protein Smoothened (SMO), which is part of the Hedgehog signal transduction pathway that is clinically relevant in diseases such as basal cell cancer.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Erivedge manufacturer side effect tips[4]
- Vismodegib (Erivedge) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 1/30/2012: Initial FDA approval "for the treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery, and who are not candidates for radiation."
Also known as
- Code name: GDC-0449
- Brand name: Erivedge