Difference between revisions of "Dactinomycin (Cosmegen)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Ewing's sarcoma]] | *[[Ewing's sarcoma]] | ||
| + | *[[Gestational trophoblastic neoplasia]] | ||
*[[Osteosarcoma]] | *[[Osteosarcoma]] | ||
*[[Soft tissue sarcoma|Rhabdomyosarcoma]] | *[[Soft tissue sarcoma|Rhabdomyosarcoma]] | ||
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==Also known as== | ==Also known as== | ||
| − | + | *'''Generic names:''' AC-DE, Actinomycin D | |
| − | + | *'''Brand names:''' Cosmegen, Dacmozen, Lyovac | |
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==References== | ==References== | ||
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[[Category:Osteosarcoma medications]] | [[Category:Osteosarcoma medications]] | ||
[[Category:Ewing's sarcoma medications]] | [[Category:Ewing's sarcoma medications]] | ||
| + | [[Category:Gestational trophoblastic neoplasia medications]] | ||
[[Category:Soft tissue sarcoma medications]] | [[Category:Soft tissue sarcoma medications]] | ||
[[Category:Uterine cancer medications]] | [[Category:Uterine cancer medications]] | ||
Revision as of 15:06, 1 February 2018
General information
Class/mechanism: Antibiotic oncologic, intercalates between guanine and cytosine DNA base pairs, inhibiting DNA and RNA synthesis.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Dactinomycin (Cosmegen) patient drug information (Chemocare)[3]
- Dactinomycin (Cosmegen) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/10/1964: Initial FDA approval
Also known as
- Generic names: AC-DE, Actinomycin D
- Brand names: Cosmegen, Dacmozen, Lyovac