Difference between revisions of "Daunorubicin (Cerubidine)"
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| + | Also known as daunomycin, daunomycin cerubidine, daunorubicin hydrochloride, or rubidomycin hydrochloride. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: Anthracycline, binds and intercalates between DNA base pairs. Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, resulting in single and double strand DNA breaks. May also inhibit polymerase activity and trigger free radical damage to DNA.<ref name="insert">[http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Ben+Venue_Bedford+Labs/55390-108-01+DNOP_AQ+20mg/5539010801 Daunorubicin (Cerubidine) package insert]</ref><ref>[ | + | Class/mechanism: Anthracycline, binds and intercalates between DNA base pairs. Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, resulting in single and double strand DNA breaks. May also inhibit polymerase activity and trigger free radical damage to DNA.<ref name="insert">[http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Ben+Venue_Bedford+Labs/55390-108-01+DNOP_AQ+20mg/5539010801 Daunorubicin (Cerubidine) package insert]</ref><ref>[[Media:Daunorubicin.pdf | Daunorubicin (Cerubidine) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[vesicant]] | <br>Extravasation: [[vesicant]] | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Acute lymphocytic leukemia]] | ||
| + | *[[Acute myeloid leukemia]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http:// | + | *[http://chemocare.com/chemotherapy/drug-info/daunorubicin.aspx Daunorubicin (Cerubidine) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/daunorubicin.aspx Daunorubicin (Cerubidine) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/daunorubicin-patient-drug-information Daunorubicin (Cerubidine) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/daunorubicin-patient-drug-information Daunorubicin (Cerubidine) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/daunorubicin-patient-drug-information Daunorubicin (Cerubidine) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/daunorubicin-patient-drug-information Daunorubicin (Cerubidine) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Vesicant chemotherapy]] | ||
| + | [[Category:Anthracyclines]] | ||
| + | [[Category:Topoisomerase inhibitors]] | ||
| + | [[Category:Acute lymphocytic leukemia medications]] | ||
| + | [[Category:Acute myeloid leukemia medications]] | ||
Revision as of 18:04, 14 October 2012
Also known as daunomycin, daunomycin cerubidine, daunorubicin hydrochloride, or rubidomycin hydrochloride.
General information
Class/mechanism: Anthracycline, binds and intercalates between DNA base pairs. Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, resulting in single and double strand DNA breaks. May also inhibit polymerase activity and trigger free radical damage to DNA.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Daunorubicin (Cerubidine) patient drug information (Chemocare)[3]
- Daunorubicin (Cerubidine) patient drug information (UpToDate)[4]