Difference between revisions of "Clofarabine (Clolar)"
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| + | Also known as Evoltra. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: Purine analog, inhibits DNA synthesis and repair by inhibiting ribonucleotide reductase and competitively inhibiting DNA polymerases. It also causes apoptosis by disrupting the integrity of the mitochondrial membrane, triggering the release of cytochrome C and apoptosis-inducing factor, which are pro-apoptotic mitochondrial proteins.<ref name="insert">[http://www.clolar.com/~/media/Files/Clolar/prescribing-information.pdf Clofarabine (Clolar) package insert]</ref><ref>[ | + | Class/mechanism: Purine analog, inhibits DNA synthesis and repair by inhibiting ribonucleotide reductase and competitively inhibiting DNA polymerases. It also causes apoptosis by disrupting the integrity of the mitochondrial membrane, triggering the release of cytochrome C and apoptosis-inducing factor, which are pro-apoptotic mitochondrial proteins.<ref name="insert">[http://www.clolar.com/~/media/Files/Clolar/prescribing-information.pdf Clofarabine (Clolar) package insert]</ref><ref>[[Media:Clofarabine.pdf | Clofarabine (Clolar) package insert (locally hosted backup)]]</ref><ref>[http://clolar.com Clolar manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Acute lymphocytic leukemia]] | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *Brief patient counseling information can be found at the bottom of [http://www.clolar.com/~/media/Files/Clolar/prescribing-information.pdf#page=2 page 2 of the package insert]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/clofarabine-patient-drug-information Clofarabine (Clolar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/clofarabine-patient-drug-information Clofarabine (Clolar) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/clofarabine-patient-drug-information Clofarabine (Clolar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/clofarabine-patient-drug-information Clofarabine (Clolar) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Nucleic acid analogs]] | ||
| + | [[Category:Acute lymphocytic leukemia medications]] | ||
Revision as of 06:24, 8 October 2012
Also known as Evoltra.
General information
Class/mechanism: Purine analog, inhibits DNA synthesis and repair by inhibiting ribonucleotide reductase and competitively inhibiting DNA polymerases. It also causes apoptosis by disrupting the integrity of the mitochondrial membrane, triggering the release of cytochrome C and apoptosis-inducing factor, which are pro-apoptotic mitochondrial proteins.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Brief patient counseling information can be found at the bottom of page 2 of the package insert[1]
- Clofarabine (Clolar) patient drug information (UpToDate)[4]