Difference between revisions of "Carmustine (BCNU)"
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| − | Also known as bischloroethylnitrosourea, BCNU. | + | Also known as bischloroethylnitrosourea, BCNU, or Carustine. |
==General information== | ==General information== | ||
| − | Class/mechanism: Nitrosourea, alkylates DNA and RNA, inhibits several key enzymatic processes by carbamoylation of amino acids in proteins.<ref name="insert">[http://packageinserts.bms.com/pi/pi_bicnu.pdf Carmustine (BiCNU) package insert]</ref><ref>[ | + | Class/mechanism: Nitrosourea, alkylates DNA and RNA, inhibits several key enzymatic processes by carbamoylation of amino acids in proteins.<ref name="insert">[http://packageinserts.bms.com/pi/pi_bicnu.pdf Carmustine (BiCNU) package insert]</ref><ref>[[Media:Carmustine.pdf | Carmustine (BiCNU) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[vesicant]]/[[irritant]] | <br>Extravasation: [[vesicant]]/[[irritant]] | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Hodgkin lymphoma]] | ||
| + | *[[Melanoma]] | ||
| + | *[[Non-Hodgkin lymphoma]] | ||
| + | *[[Transplant conditioning regimens]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/carmustine.aspx Carmustine (BiCNU) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/carmustine.aspx Carmustine (BiCNU) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/carmustine-patient-drug-information Carmustine (BiCNU) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/carmustine-patient-drug-information Carmustine (BiCNU) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/carmustine-patient-drug-information Carmustine (BiCNU) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/carmustine-patient-drug-information Carmustine (BiCNU) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Nitrogen mustards]] | ||
| + | [[Category:Alkylating agents]] | ||
| + | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Melanoma medications]] | ||
| + | [[Category:Non-Hodgkin lymphoma medications]] | ||
| + | [[Category:Transplant medications]] | ||
| + | [[Category:Irritant chemotherapy]] | ||
| + | [[Category:Vesicant chemotherapy]] | ||
Revision as of 04:56, 8 October 2012
Also known as bischloroethylnitrosourea, BCNU, or Carustine.
General information
Class/mechanism: Nitrosourea, alkylates DNA and RNA, inhibits several key enzymatic processes by carbamoylation of amino acids in proteins.[1][2]
Route: IV
Extravasation: vesicant/irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Carmustine (BiCNU) patient drug information (Chemocare)[3]
- Carmustine (BiCNU) patient drug information (UpToDate)[4]