Difference between revisions of "Bendamustine"
Jump to navigation
Jump to search
m (Text replace - "package insert<ref name="insert"></ref>." to "prescribing information.<ref name="insert"></ref>") |
(updated content) |
||
| Line 1: | Line 1: | ||
| + | Also known as Bendamustine Hydrochloride, Ribomustin, SDX-105, or Treakisym. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: Nitrogen mustard, alkylator; bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring which forms electrophilic alkyl groups, resulting in interstrand DNA crosslinks, leading to cell death via several pathways in both quiescent and dividing cells.<ref name="insert">[http://www.treanda.com/pdf/TREANDA_final_PI.pdf Bendamustine (Treanda) package insert]</ref><ref>[ | + | Class/mechanism: Nitrogen mustard, alkylator; bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring which forms electrophilic alkyl groups, resulting in interstrand DNA crosslinks, leading to cell death via several pathways in both quiescent and dividing cells.<ref name="insert">[http://www.treanda.com/pdf/TREANDA_final_PI.pdf Bendamustine (Treanda) package insert]</ref><ref>[[Media:Bendamustine.pdf | Bendamustine (Treanda) package insert (locally hosted backup)]]</ref><ref>[http://treanda.com/ Treanda manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]] | ||
| + | *[[Non-Hodgkin lymphoma]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/bendamustine.aspx Bendamustine (Treanda) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/bendamustine.aspx Bendamustine (Treanda) patient drug information (Chemocare)]</ref> |
| + | *Brief patient counseling information can be found on [http://www.treanda.com/pdf/TREANDA_final_PI.pdf#page=7 page 7 of the package insert]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/bendamustine-patient-drug-information Bendamustine (Treanda) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/bendamustine-patient-drug-information Bendamustine (Treanda) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/bendamustine-patient-drug-information Bendamustine (Treanda) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/bendamustine-patient-drug-information Bendamustine (Treanda) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 17:55, 7 October 2012
Also known as Bendamustine Hydrochloride, Ribomustin, SDX-105, or Treakisym.
General information
Class/mechanism: Nitrogen mustard, alkylator; bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring which forms electrophilic alkyl groups, resulting in interstrand DNA crosslinks, leading to cell death via several pathways in both quiescent and dividing cells.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Bendamustine (Treanda) patient drug information (Chemocare)[4]
- Brief patient counseling information can be found on page 7 of the package insert[1]
- Bendamustine (Treanda) patient drug information (UpToDate)[5]