Difference between revisions of "Dinaciclib (SCH-727965)"
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===[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]]=== | ===[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]]=== | ||
| − | # Flynn J, Jones J, Johnson AJ, Andritsos L, Maddocks K, Jaglowski S, Hessler J, Grever MR, Im E, Zhou H, Zhu Y, Zhang D, Small K, Bannerji R, Byrd JC. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia. 2015 Feb 24. | + | # Flynn J, Jones J, Johnson AJ, Andritsos L, Maddocks K, Jaglowski S, Hessler J, Grever MR, Im E, Zhou H, Zhu Y, Zhang D, Small K, Bannerji R, Byrd JC. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia. 2015 Jul;29(7):1524-9. Epub 2015 Feb 24. [http://www.nature.com/leu/journal/v29/n7/full/leu201531a.html link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551390/ link to PMC article] [https://www.ncbi.nlm.nih.gov/pubmed/25708835 PubMed] |
===[[Multiple myeloma]]=== | ===[[Multiple myeloma]]=== | ||
| − | # Kumar SK, LaPlant B, Chng WJ, Zonder J, Callander N, Fonseca R, Fruth B, Roy V, Erlichman C, Stewart AK. Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single agent activity in patients with relapsed multiple myeloma. Blood. 2014 Nov 13. | + | # Kumar SK, LaPlant B, Chng WJ, Zonder J, Callander N, Fonseca R, Fruth B, Roy V, Erlichman C, Stewart AK. Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single agent activity in patients with relapsed multiple myeloma. Blood. 2015 Jan 15;125(3):443-8. Epub 2014 Nov 13. [http://www.bloodjournal.org/content/125/3/443 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25395429/ link to PMC article] [https://www.ncbi.nlm.nih.gov/pubmed/25395429 PubMed] |
[[Category:Drug index]] | [[Category:Drug index]] | ||
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[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
Revision as of 15:46, 8 October 2017
Mechanism of action
A cyclin dependent kinase inhibitor that selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9.
Preliminary data
Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- Flynn J, Jones J, Johnson AJ, Andritsos L, Maddocks K, Jaglowski S, Hessler J, Grever MR, Im E, Zhou H, Zhu Y, Zhang D, Small K, Bannerji R, Byrd JC. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia. 2015 Jul;29(7):1524-9. Epub 2015 Feb 24. link to original article link to PMC article PubMed
Multiple myeloma
- Kumar SK, LaPlant B, Chng WJ, Zonder J, Callander N, Fonseca R, Fruth B, Roy V, Erlichman C, Stewart AK. Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single agent activity in patients with relapsed multiple myeloma. Blood. 2015 Jan 15;125(3):443-8. Epub 2014 Nov 13. link to original article link to PMC article PubMed