Difference between revisions of "Example orders for 5-FU & high-dose Leucovorin (Roswell Park regimen - HDLV) in colon cancer"
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==5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV)== | ==5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV)== | ||
| − | Original | + | Original references may be found at [[Colon_cancer#Fluorouracil_.285-FU.29_.26_Folinic_acid_.28Leucovorin.29|5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (adjuvant)]] & [[Colon_cancer#Fluorouracil_.285-FU.29_.26_Folinic_acid_.28Leucovorin.29_2|5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (metastatic)]] |
===Example regimen #1=== | ===Example regimen #1=== | ||
Revision as of 16:36, 3 July 2012
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.
5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV)
Original references may be found at 5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (adjuvant) & 5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (metastatic)
Example regimen #1
- Folinic acid (Leucovorin) 500 mg/m2 IV over 2 hours on days 1, 8, 15, 22, 29, 36, given first
- Fluorouracil (5-FU) 500 mg/m2 IV push on days 1, 8, 15, 22, 29, 36, 1 hour after start of leucovorin
8-week cycles x 3-4 cycles for adjuvant therapy; in metastatic settings, given until progression of disease or unacceptable toxicity
Supportive medications:
- Prochlorperazine (Compazine) 10 mg PO 30 minutes prior to chemotherapy
- Ondansetron (Zofran) 8 mg IV prn nausea
- Dexamethasone (Decadron) 10 mg IV prn nausea
Hydration:
- 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.
Monitoring:
- Hold if patient has significant diarrhea/mucositis, ANC <1000, or platelets <100 and notify physician.