Difference between revisions of "Procarbazine (Matulane)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Hydrazine, alkylator; exact mechanism not understood. May inhibit transmethylation of methionine methyl groups to tRNA, interfering with protein, RNA, and DNA synthesis. May also directly damage DNA.<ref name="insert">[http://www.matulane.com/pdf/prescribe-info.pdf Procarbazine (Matulane) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/procarbazine.pdf Procarbazine (Matulane) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Hydrazine derivative, alkylator; exact mechanism not understood. May inhibit transmethylation of methionine methyl groups to tRNA, interfering with protein, RNA, and DNA synthesis. May also directly damage DNA.<ref name="insert">[http://www.matulane.com/pdf/prescribe-info.pdf Procarbazine (Matulane) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/procarbazine.pdf Procarbazine (Matulane) package insert (locally hosted backup)]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
Revision as of 19:32, 24 February 2012
Also known as Natulan or Indicarb.
General information
Class/mechanism: Hydrazine derivative, alkylator; exact mechanism not understood. May inhibit transmethylation of methionine methyl groups to tRNA, interfering with protein, RNA, and DNA synthesis. May also directly damage DNA.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Procarbazine (Matulane) patient drug information (Chemocare)[3]
- Procarbazine (Matulane) patient drug information (UpToDate)[4]