Difference between revisions of "Nelarabine (Arranon)"
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m (moved Nelerabine (Arranon) to Nelarabine (Arranon): spelling) |
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| + | Also known as Atriance. | ||
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf Nelarabine (Arranon) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/nelarabine.pdf Nelarabine (Arranon) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Purine analog, antimetabolite. Nelarabine is metabolized to the cytotoxic deoxyguanosine analogue, 9-β-Darabinofuranosylguanine (ara-G), which is eventually converted to ara-GTP. ara-GTP is incorporated into DNA and leads to inhibition of DNA synthesis and cell death.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf Nelarabine (Arranon) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/nelarabine.pdf Nelarabine (Arranon) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: no information |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf#page=17 Nelarabine (Arranon) package insert PDF pages 17-19]<ref name="insert"></ref> | ||
*[http://chemocare.com/bio/nelarabine.asp Nelarabine (Arranon) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/nelarabine.asp Nelarabine (Arranon) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/nelarabine.asp Nelarabine (Arranon) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/nelarabine.asp Nelarabine (Arranon) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/nelarabine-patient-drug-information Nelarabine (Arranon) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/nelarabine-patient-drug-information Nelarabine (Arranon) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/nelarabine-patient-drug-information Nelarabine (Arranon) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/nelarabine-patient-drug-information Nelarabine (Arranon) patient drug information (UpToDate)]</ref> | ||
Revision as of 20:38, 23 February 2012
Also known as Atriance.
General information
Class/mechanism: Purine analog, antimetabolite. Nelarabine is metabolized to the cytotoxic deoxyguanosine analogue, 9-β-Darabinofuranosylguanine (ara-G), which is eventually converted to ara-GTP. ara-GTP is incorporated into DNA and leads to inhibition of DNA synthesis and cell death.[1][2]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Nelarabine (Arranon) package insert PDF pages 17-19[1]
- Nelarabine (Arranon) patient drug information (Chemocare)[3]
- Nelarabine (Arranon) patient drug information (UpToDate)[4]