Difference between revisions of "Carmofur (HCFU)"
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[[Category:Fluoropyrimidines]] | [[Category:Fluoropyrimidines]] | ||
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Latest revision as of 22:20, 1 October 2023
General information
Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Converted in vivo to fluorouracil (5-FU), which is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).[1][2][3]
Route: PO
Extravasation: n/a
Also known as
- Generic names: HCFU, hexylcarbamoyl fluorouracil