Difference between revisions of "Tirapazamine (Tirazone)"
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m (Jwarner moved page Tirapazamine (SR 4233) to Tirapazamine (Tirazone): brand name) |
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==Mechanism of action== | ==Mechanism of action== | ||
| − | From the NCI Drug Dictionary: A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. | + | From the [https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tirapazamine NCI Drug Dictionary]: A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. |
==Also known as== | ==Also known as== | ||
| − | *'''Code | + | *'''Code names:''' SR-4233, WIN-59075 |
*'''Brand name:''' Tirazone | *'''Brand name:''' Tirazone | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
| + | [[Category:Intravenous medications]] | ||
[[Category:Investigational drugs]] | [[Category:Investigational drugs]] | ||
[[Category:Stub]] | [[Category:Stub]] | ||
Latest revision as of 02:06, 26 July 2023
Mechanism of action
From the NCI Drug Dictionary: A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II.
Also known as
- Code names: SR-4233, WIN-59075
- Brand name: Tirazone