Difference between revisions of "Tirapazamine (Tirazone)"
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m (Jwarner moved page Tirapazamine (SR 4233) to Tirapazamine (Tirazone): brand name) |
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Revision as of 22:35, 20 June 2023
Mechanism of action
From the NCI Drug Dictionary: A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II.
Also known as
- Code name: SR 4233
- Brand name: Tirazone