Difference between revisions of "Thiotepa (Thioplex)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Alkylator, ethylenimine-type, similar to nitrogen mustards. Ethylenimine radicals are released, which alkylates at the N7 position of guanine, resulting in the linkage between the purine and sugar being severed, and subsequent cell damage and death.<ref name="insert">[ | + | Class/mechanism: Alkylator, ethylenimine-type, similar to nitrogen mustards. Ethylenimine radicals are released, which alkylates at the N7 position of guanine, resulting in the linkage between the purine and sugar being severed, and subsequent cell damage and death.<ref name="insert">[https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208264s000lbl.pdf Thiotepa (Thioplex/Tepadina) package insert]</ref><ref>[[Media:Thiotepa.pdf | Thiotepa (Thioplex/Tepadina) package insert (locally hosted backup)]]</ref> |
<br>Route: IV, intravesicular, intracavitary; (off-label: IT) | <br>Route: IV, intravesicular, intracavitary; (off-label: IT) | ||
| − | <br>Extravasation: [[irritant]] | + | <br>Extravasation: [[irritant]] or [[neutral]], depending on reference |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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*[[Bladder cancer]] | *[[Bladder cancer]] | ||
*[[CNS lymphoma]] | *[[CNS lymphoma]] | ||
| + | *[[Peripheral T-cell lymphoma]] | ||
| + | *[[Transplant conditioning regimens]] | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *Patient counseling information can be found in the [https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208264s000lbl.pdf Thiotepa (Thioplex/Tepadina) package insert]<ref name="insert"></ref> | ||
*[http://chemocare.com/bio/thiotepa.asp Thiotepa (Thioplex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/thiotepa.asp Thiotepa (Thioplex) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/thiotepa.asp Thiotepa (Thioplex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/thiotepa.asp Thiotepa (Thioplex) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/thiotepa-patient-drug-information Thiotepa (Thioplex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/thiotepa-patient-drug-information Thiotepa (Thioplex) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/thiotepa-patient-drug-information Thiotepa (Thioplex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/thiotepa-patient-drug-information Thiotepa (Thioplex) patient drug information (UpToDate)]</ref> | ||
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
* 3/9/1959: Initial FDA approval | * 3/9/1959: Initial FDA approval | ||
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| + | ==Also known as== | ||
| + | Tepadina, Thioplex, TESPA, Thiophosphoamide, or TSPA. | ||
==References== | ==References== | ||
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[[Category:Intravenous chemotherapy]] | [[Category:Intravenous chemotherapy]] | ||
[[Category:Intravesicular chemotherapy]] | [[Category:Intravesicular chemotherapy]] | ||
| + | [[Category:Irritant chemotherapy]] | ||
| + | [[Category:Neutral chemotherapy]] | ||
[[Category:Alkylating agents]] | [[Category:Alkylating agents]] | ||
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[[Category:Bladder cancer medications]] | [[Category:Bladder cancer medications]] | ||
[[Category:Central nervous system (CNS) lymphoma medications]] | [[Category:Central nervous system (CNS) lymphoma medications]] | ||
| + | [[Category:Transplant medications]] | ||
| + | [[Category:T-cell lymphoma medications]] | ||
[[Category:Drugs FDA approved in 1959]] | [[Category:Drugs FDA approved in 1959]] | ||
Revision as of 21:26, 23 April 2017
General information
Class/mechanism: Alkylator, ethylenimine-type, similar to nitrogen mustards. Ethylenimine radicals are released, which alkylates at the N7 position of guanine, resulting in the linkage between the purine and sugar being severed, and subsequent cell damage and death.[1][2]
Route: IV, intravesicular, intracavitary; (off-label: IT)
Extravasation: irritant or neutral, depending on reference
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Patient counseling information can be found in the Thiotepa (Thioplex/Tepadina) package insert[1]
- Thiotepa (Thioplex) patient drug information (Chemocare)[3]
- Thiotepa (Thioplex) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 3/9/1959: Initial FDA approval
Also known as
Tepadina, Thioplex, TESPA, Thiophosphoamide, or TSPA.
References
Categories:
- Drug index
- Chemotherapy
- Intracavitary chemotherapy
- Intrathecal chemotherapy
- Intravenous chemotherapy
- Intravesicular chemotherapy
- Irritant chemotherapy
- Neutral chemotherapy
- Alkylating agents
- Bladder cancer medications
- Central nervous system (CNS) lymphoma medications
- Transplant medications
- T-cell lymphoma medications
- Drugs FDA approved in 1959