Difference between revisions of "Dalteparin (Fragmin)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Low molecular weight heparin, binds to antithrombin III, accelerating its activity and inhibiting factor Xa and thrombin.<ref name="insert">[http:// | + | Class/mechanism: Low molecular weight heparin, binds to antithrombin III, accelerating its activity and inhibiting factor Xa and thrombin.<ref name="insert">[http://labeling.pfizer.com/ShowLabeling.aspx?id=2293 Dalteparin (Fragmin) package insert]</ref><ref>[[Media:Dalteparin.pdf | Dalteparin (Fragmin) package insert (locally hosted backup)]]</ref><ref>[https://www.pfizerinjectables.com/products/Fragmin Fragmin manufacturer's website]</ref> |
<br>Route: SC | <br>Route: SC | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
| Line 7: | Line 7: | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *Brief patient counseling information can be found in [http:// | + | *Brief patient counseling information can be found in [http://labeling.pfizer.com/ShowLabeling.aspx?id=2293 the Dalteparin (Fragmin) package insert]<ref name="insert"></ref> |
*[http://www.uptodate.com/contents/dalteparin-patient-drug-information Dalteparin (Fragmin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dalteparin-patient-drug-information Dalteparin (Fragmin) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/dalteparin-patient-drug-information Dalteparin (Fragmin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dalteparin-patient-drug-information Dalteparin (Fragmin) patient drug information (UpToDate)]</ref> | ||
Revision as of 23:51, 26 April 2017
General information
Class/mechanism: Low molecular weight heparin, binds to antithrombin III, accelerating its activity and inhibiting factor Xa and thrombin.[1][2][3]
Route: SC
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Brief patient counseling information can be found in the Dalteparin (Fragmin) package insert[1]
- Dalteparin (Fragmin) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/22/1994: Initial FDA approval "for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE) in patients undergoing hip replacement surgery."
- Subsequently FDA approved for "Prophylaxis of deep vein thrombosis (DVT) in abdominal surgery, hip replacement surgery or medical patients with severely restricted mobility during acute illness" and "Extended treatment of symptomatic venous thromboembolism (VTE) to reduce the recurrence in patients with cancer. In these patients, the FRAGMIN therapy begins with the initial VTE treatment and continues for six months."
Also known as
Precise Name: Dalteparin sodium (RXCUI 82137)
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Daltepan | Daltepin | Fluzepamin | Fragmin | Fragmine | Fragminject | Fresubaru | HAI PU Ning |
| Hepachron | Hepagumin | Heparin LMW | JI PAI LIN | Ligofragmin | Low Liquemin | QI Zheng | Resolmin |
| SU KE NUO | Tedelparin Sodium | ||||||